Myocardial perfusion and microvascular dysfunction in stable coronary artery disease during hyperoxaemia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN67819491

Enrollment

Registered

2014-08-14

Start date

2014-09-01

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Topic: Cardiovascular disease

Interventions

Administration of high flow oxygen

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients: Known coronary artery disease involving one or more major epicardial vessels (=2.5mm diameter) with severe coronary artery disease (coronary luminal stenosis severity =70% or FFR =0.8). For the healthy volunteer group: No known risk factors for underlying coronary artery disease

Exclusion criteria

Exclusion criteria: 1. Clinically unstable 2. Previous coronary artery bypass grafting 3. Contraindication to adenosine (regular adenosine antagonist medication, significant reversible airways disease, second or third degree atrioventricular heart block, sinoatrial disease) 4. Pregnancy or breast feeding 5. Recent acute coronary syndrome (<6 weeks) 6. Nonsinus rhythm 7. Chronic obstructive airways disease with a history of hypercapnic respiratory failure 8. Three vessel coronary artery disease 9. Claustrophobia 10. Known adverse reaction to adenosine or iodinated contrast agents

Design outcomes

Primary

Measure	Time frame
Quantificaton of myocardial blood flow; timepoint(s): unspecified	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026