A Maudsley outpatient study of treatments for anorexia nervosa and related conditions

A randomised controlled trial of the Maudsley Model of Treatment for Adults with Anorexia Nervosa (MANTRA) compared to specialist supportive clinical management (SSCM) in outpatients with anorexia nervosa or eating disorder not otherwise specified (ED-NOS)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN67720902

Enrollment

140

Registered

2010-04-15

Start date

2010-04-01

Completion date

Unknown

Last updated

2017-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia nervosa (AN)/eating disorder not otherwise specified (EDNOS). Mental and Behavioural Disorders Eating disorders

Interventions

MANTRA: A cognitive interpersonal therapy which aims to target factors involved in the development and maintenance of AN, including: 1. Thinking styles 2. Social-emotional factors 3. Pro-anorexia bel

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18 years and above, either sex 2. Meet Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria for anorexia nervosa or AN-type eating disorder not otherwise specified (EDNOS) 3. Body mass index (BMI) below 18.5 kg/m^2

Exclusion criteria

Exclusion criteria: 1. Life-threatening AN requiring immediate hospitalisation or in-patient treatment 2. Insufficient knowledge of English to understand treatment and assessments 3. Learning difficulty 4. Mental or physical illness requiring treatment in its own right 5. Substance dependence 6. Pregnancy

Design outcomes

Primary

Measure	Time frame
Current primary outcome measures as of 26/10/2012: Body mass index (BMI; kg/m^2), and Eating Disorders Examination (EDE) Global Score to assess eating disorder symptomology. Outcomes will be measured at baseline, 6 months, 12 months and 24 months. Potential mediators and moderators will be examined at 3 months. Previous primary outcome measures until 26/10/2012: Body mass index (BMI; kg/m^2), and Eating Disorders Examination (EDE) Global Score to assess eating disorder symptomology. Outcomes will be measured at baseline, 6 months, and 12 months. Potential mediators and moderators will be examined at 3 months. Some long term outcomes will be measured at 24 months - BMI, Eating Disorders Examination, Client Services Reciept Interview and Clinical Impairment Assessment.	—

Measure

Time frame

Current primary outcome measures as of 26/10/2012: Body mass index (BMI; kg/m^2), and Eating Disorders Examination (EDE) Global Score to assess eating disorder symptomology. Outcomes will be measured at baseline, 6 months, 12 months and 24 months. Potential mediators and moderators will be examined at 3 months. Previous primary outcome measures until 26/10/2012: Body mass index (BMI; kg/m^2), and Eating Disorders Examination (EDE) Global Score to assess eating disorder symptomology. Outcomes will be measured at baseline, 6 months, and 12 months. Potential mediators and moderators will be examined at 3 months. Some long term outcomes will be measured at 24 months - BMI, Eating Disorders Examination, Client Services Reciept Interview and Clinical Impairment Assessment.

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Secondary

Measure	Time frame
Current secondary outcome measures as of 26/10/2012: 1. EDE subscale scores 2. Depression, Anxiety and Stress Scale (DASS-21) 3. Obsessive Compulsive Inventory (OCI) 4. The Cognitive Flexibility Scale 5. Beliefs about Emotions Scale 6. Emotion Regulation Questionnaire 7. Motivational and Social Visual Analogue Scales 8. Client Services Receipt Interview (CSRI) 9. The Clinical Impairment Assessment (CIA) 10. Treatment credibility and acceptability Visual Analogue Scales 11. Neurocognitive measures: 11.1. Brixton Spatial Anticipation Task 11.2. Wisconsin Card Sorting Task 11.3. Rey-Osterreith Complex Figure Test 12. Social Cognitive Measures: 12.1 Reading the Mind in the Film Outcomes will be measured at baseline, 6 months, 12 months and 24 months. Potential mediators and moderators will be examined at 3 months. Previous secondary outcome measures until 26/10/2012: 1. EDE subscale scores 2. Depression, Anxiety and Stress Scale (DASS-21) 3. Obsessive Compulsive Inventory (OCI) 4. Cognitive Behavioural Transprocesses Questionnaire 5. Social Comparison Rating Scale 6. The Vulnerable Attachment Style Questionnaire (VASQ) 7. The Cognitive Flexibility Scale 8. Beliefs about Emotions Scale 9. Emotion Regulation Questionnaire 10. Motivational and Social Visual Analogue Scales 11. Client Services Receipt Interview (CSRI) 12. The Clinical Impairment Assessment (CIA) 13. Treatment credibility and acceptability Visual Analogue Scales 14. Neurocognitive measures: 14.1. Brixton Spatial Anticipation Task 14.2. Trail Making Task 14.3. Rey-Osterreith Complex Figure Test 15. Social Cognitive Measures: Reading the Mind in the Film and Interpersonal Perception Task 16. Genetic measures: Cheek swab for genotyping Outcomes will be measured at baseline, 6 months, and 12 months. Potential mediators and moderators will be examined at 3 months. Some long term outcomes will be measured at 24 months - BMI, Eating Disorders Examination, Client Services Reciept Interview and Cli	—

Measure

Time frame

Current secondary outcome measures as of 26/10/2012: 1. EDE subscale scores 2. Depression, Anxiety and Stress Scale (DASS-21) 3. Obsessive Compulsive Inventory (OCI) 4. The Cognitive Flexibility Scale 5. Beliefs about Emotions Scale 6. Emotion Regulation Questionnaire 7. Motivational and Social Visual Analogue Scales 8. Client Services Receipt Interview (CSRI) 9. The Clinical Impairment Assessment (CIA) 10. Treatment credibility and acceptability Visual Analogue Scales 11. Neurocognitive measures: 11.1. Brixton Spatial Anticipation Task 11.2. Wisconsin Card Sorting Task 11.3. Rey-Osterreith Complex Figure Test 12. Social Cognitive Measures: 12.1 Reading the Mind in the Film Outcomes will be measured at baseline, 6 months, 12 months and 24 months. Potential mediators and moderators will be examined at 3 months. Previous secondary outcome measures until 26/10/2012: 1. EDE subscale scores 2. Depression, Anxiety and Stress Scale (DASS-21) 3. Obsessive Compulsive Inventory (OCI) 4. Cognitive Behavioural Transprocesses Questionnaire 5. Social Comparison Rating Scale 6. The Vulnerable Attachment Style Questionnaire (VASQ) 7. The Cognitive Flexibility Scale 8. Beliefs about Emotions Scale 9. Emotion Regulation Questionnaire 10. Motivational and Social Visual Analogue Scales 11. Client Services Receipt Interview (CSRI) 12. The Clinical Impairment Assessment (CIA) 13. Treatment credibility and acceptability Visual Analogue Scales 14. Neurocognitive measures: 14.1. Brixton Spatial Anticipation Task 14.2. Trail Making Task 14.3. Rey-Osterreith Complex Figure Test 15. Social Cognitive Measures: Reading the Mind in the Film and Interpersonal Perception Task 16. Genetic measures: Cheek swab for genotyping Outcomes will be measured at baseline, 6 months, and 12 months. Potential mediators and moderators will be examined at 3 months. Some long term outcomes will be measured at 24 months - BMI, Eating Disorders Examination, Client Services Reciept Interview and Cli

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Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 26, 2026