Asthma diagnosis in primary care Respiratory
Conditions
Interventions
Current methodology as of 11/05/2026:
Suspected asthma participants will present to their GP Surgery with symptoms suggestive of Asthma. If their GP thinks that they are potentially eligible to take p
we will not be involved in the clinical diagnosis of any participants. After this visit, the healthy volunteers involvement is complete.
The suspect asthma participants will complete two weeks of hom
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: All: 1. Participant is willing and able to give informed consent for participation in the study 2. Aged 18 to 59 years Suspected Asthma (SA) cohort: 1. Presenting to primary care with symptoms suggestive of asthma, e.g., breathlessness and/or wheeze and/or cough where the clinician would normally initiate further investigations for potential asthma
Exclusion criteria
Exclusion criteria: Current exclusion criteria as of 11/05/2026: All: 1. Current or ex-smoker (including tobacco, cannabis and e-cigarettes). Having smoked less than 100 cigarettes in their lifetime can be included (as per CDC definition of a never-smoker), provided last smoking was at least a year ago. 2. Pre-existing or previously diagnosed chronic respiratory disease including asthma (resolved diagnoses or previous short-term treatments for asthma or other respiratory disease such as preschool wheeze labelled as asthma are eligible for inclusion) 3. Other current/recent medical condition which affects breathing or the immune system (hay fever/atopy can be included) 4. Current regular use of an inhaled steroid/long-acting bronchodilator or systemic immunosuppression (nasal steroids, or use of short-acting bronchodilators is allowed). Where possible, we will wait 6 weeks post-oral steroid course before diagnostic testing, as is recommended in clinical guidelines, unless there is a relevant clinical reason to do this sooner, as determined by the PI/usual GP. 5. Currently pregnant (this is due to the contra-indication to spirometry testing when pregnant, due to physiological changes and forced exhalations resulting from the reduced lung capacity, therefore we will not require formal pregnancy testing before participation) 6. Unstable/severe symptoms and/or any safety concerns which would make diagnostic assessment in a non-clinical research setting inappropriate for them or the research staff. Healthy control cohort: As above for ‘All’ and: 1. Current respiratory symptoms or suspicion of asthma or other chronic respiratory disease diagnosis 2. Childhood diagnosis of asthma or other chronic respiratory problems in childhood, including preschool wheeze Previous exclusion criteria: All: 1. Current or ex-smoker (including tobacco, cannabis and e-cigarettes). Having smoked less than 100 cigarettes in their lifetime can be included (as per CDC definition of a never-smoker), provided last smoking was at least a year ago. 2. Pre-existing or previously diagnosed chronic respiratory disease including asthma (resolved diagnoses or previous short-term treatments for asthma or other respiratory disease such as preschool wheeze labelled as asthma are eligible for inclusion) 3. Other current/recent medical condition which affects breathing or the immune system (hay fever/atopy can be included) 4. Current or recent (last 2 weeks) use of oral/long-acting inhaled bronchodilator or steroid or systemic immunosuppression (nasal steroids, or use of short-acting bronchodilators is allowed) 5. Currently pregnant (this is due to the contra-indication to spirometry testing when pregnant, due to physiological changes and forced exhalations resulting from the reduced lung capacity, therefore we will not require formal pregnancy testing before participation) 6. Unstable/severe symptoms and/or any safety concerns which would make diagnostic assessment in a non-clinical research setting inappropriate for them or the research staff. Healthy control cohort: As above for ‘All’ and: 1. Current respiratory symptoms or suspicion of asthma or other chronic respiratory disease diagnosis 2. Childhood diagnosis of asthma or other chronic respiratory problems in childhood, including preschool wheeze
Countries
England, United Kingdom
Contacts
Public ContactJohanna;Zhanna Cook;Oganesova
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Outcome results
None listed