Cardiovascular: Heart failure Circulatory System Heart failure
Conditions
Interventions
This is a randomised controlled trial comparing a course (35 sessions over 4 to 7 weeks) of standard (one hour) versus brief (5 minutes) sessions of EECP in patients with ischaemic heart disease and l
Sponsors
Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Blood and urinary samples will be collected for the purpose of this study. Blood samples will be collected by a medical doctor or specialist nurse according to standard venesection method. 6mls of the blood will be analysed immediately by the local laboratory for NT-BNP, Troponin-T and hs-CRP. The other 8mls will be centrifuged and the plasma will be stored below -20 degree celcius. These will later be analysed using commercially available kits (R & D System, Abingdon, UK) for VEGF, bFGF, HGF, IL-1beta, IL-6 and TNF-a. This will be carried out by experience doctor with support from laboratory technician within the department. 24-hour urinary collection will be analysed in the local laboratory. Inclusion criteria: 1. Over 18 years old 2. Male or female 3. Presence of LVSD with ejection fraction less than 40% 4. Known IHD stable on treatment 3 months prior to randomisation
Exclusion criteria
Exclusion criteria: 1. Patients who have had an ischaemic event within the last 3 months 2. Contraindication to EECP
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Improvement in left ventricular function and coronary perfusion reserve based on assessment by gadolinium-enhanced rest/stress (adenosine) cine CMR. 2. To confirm the hypothesis that the degree of improvement in left ventricular function is affected by the extent of viable myocardium. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed