Growth and body composition in undernourished children: effect of vitamin B12 supplementation

Growth and body composition in acute severe malnutrition (SAM) in Indian children: effect of vitamin B12 supplementation in a double-blind randomised controlled pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN67437725

Enrollment

100

Registered

2010-11-15

Start date

2010-07-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute severe malnutrition (SAM) Nutritional, Metabolic, Endocrine Malnutrition

Interventions

Oral supplementation with multiple micronutrients, with and without vitamin B12. 10 g sachets of multiple micronutrients were prepared (as per IOM RDA for 3 year olds)

patients were given 1 sachet/day orally (provided in color coded sachets). Total duration of treatment was 6 months.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Children less than or equal to -3 sd weight for height, as per World Health Organization (WHO) growth standards, aged 6 - 36 months

Exclusion criteria

Exclusion criteria: Children with acute illness or with incapacitating congenital malformation

Design outcomes

Primary

Measure	Time frame
1. Total body water, measured by D2O dilution method, measured at baseline and visit 5 2. Bio-impedance analysis, measured at baseline, visit 3 and visit 5	—

Secondary

Measure	Time frame
1. Anthropometry, measured at baseline and visit 5 2. Blood measurements, measured at baseline and visit 5	—

Countries

India

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026