Unilateral randomised double-blind placebo-controlled continuation of existing open-labelled intraputaminal GDNF (glial derived neurotrophic factor) infusion study for 6-months in subjects with idiopathic Parkinsons disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN67335687

Enrollment

Registered

2003-09-12

Start date

2003-03-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease Nervous System Diseases Parkinson's disease

Interventions

Unilateral randomised double-blind placebo controlled study.

Eligibility

Inclusion criteria

Inclusion criteria: Five patients currently enrolled in the open labelled study.

Exclusion criteria

Exclusion criteria: Does not meet inclusion criteria

Design outcomes

Primary

Measure	Time frame
1. Unified Parkinson's disease Rating Scores (UPDRS) - total and lateralised scores. 2. Timed motor tests. 3. Patient diary assessments. 4. Quality of life measures - PDQ-39 and SF-36. 5. Change in medication requirement. 18F-dopa positron emission tomography (PET) changes. 6. Safety assessments.	—

Secondary

Measure	Time frame
Not provided at time of registration	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026