Hepatitis B virus Infections and Infestations Hepatitis B virus
Conditions
Interventions
This trial will take place in five parts:
1. An open label study in five healthy volunteers, of modified vaccinia virus Ankara (MVA.HBs) (a novel vaccine for HBV), then an open label non-randomised st
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Chronic HBV infection 2. Male, 15 to 25 years 3. No evidence of liver inflammation or liver dysfunction
Exclusion criteria
Exclusion criteria: 1. Egg allergy 2. Serious disorder of any body system
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Local tolerogenicity 2. Adverse events 3. Cellular immune responses to overlapping peptides of Hepatitis B surface protein 4. HBV serology 5. Anti-HBs levels, surface antigen 6. 'e' antigen 7. HBV viral load | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
Gambia
Outcome results
None listed