ABICUS trial

Autologous Bone Marrow Implantation University of Southampton (ABICUS) versus Microfracture in the knee

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN67230654

Enrollment

Registered

2013-06-06

Start date

2013-07-01

Completion date

Unknown

Last updated

2020-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal surgery Musculoskeletal Diseases

Interventions

1. Group 1: microfracture 2. Group 2: ABICUS (Autologous Bone Marrow Implantation University of Southampton) procedure

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participant is willing and able to give informed consent for participation in the study 2. Male or female, aged 18 years to 65 years 3. Diagnosed with articular cartilage defect in the knee as assessed on MRI scan 4. No other significant medical comorbidities (medical diseases) 5. Able and willing to comply with all study requirements

Exclusion criteria

Exclusion criteria: 1. Generalised and/or inflammatory arthritis 2. Active joint inflammation 3. Obvious deformity in the knee 4. Age below 18 and over 65 years 5. Significant medical comorbidities

Design outcomes

Primary

Measure	Time frame
Clinical function, measured by the mean Lysholm, Knee injury and Osteoarthritis Outcome Score (KOOS) and International Knee Documentation Committee (IKDC) scoring scales at 6 weeks, 3 months, 6 months, 1 and 2 years post-operatively	—

Secondary

Measure	Time frame
Cartilage growth, assessed by MRI [Magnetic resonance Observation of CArtilage Repair Tissue (MOCART) score] at 1 and 2 years post-operatively	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026