Postoperative cognitive dysfunction Mental and Behavioural Disorders Postoperative cognitive dysfunction
Conditions
Interventions
Participants are randomised with computer software program for block randomization and divided into general or regional anesthesia group. If a patient had a contradiction for their anesthesia type ran
Sponsors
Ahi Evran University Medical Faculty
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for elective total knee arthroplasty (TKA) 2. Aged 15 5. Unilateral cases
Exclusion criteria
Exclusion criteria: 1. Patients >90 2. Emergent cases 3. Patients with prior psychiatric or neurologic disorders 4. Patients using steroid medications 5. Uncontrolled diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive dysfunction changes is measured using the Mini mental test (MMS), The Cognitive Failure Questionnaire (CFQ), Auditory Verbal Learning Test (AVLT) and Stroop Interference Test (SIT) at 1st preoperative, 7th and 30th postoperative days. | — |
Secondary
| Measure | Time frame |
|---|---|
| The association of the biomarkers of surgical stress (CRP, insulin, cortisol glucose) and anesthetic technique applied (general or regional) is measured using routine kits at before 15 minutes before anesthesia induction (preoperative), 1st hour during operation, 3rd and 24th hours after operation. | — |
Countries
Turkey
Outcome results
None listed