Physical function Not Applicable
Conditions
Interventions
All participants will receive 10 weeks of supervised exercise training followed by 10 weeks of unsupervised home based training. They will be randomised to receive either Perindopril 4 mg or placebo f
Sponsors
University of Dundee (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 65 years or over, either sex 2. An impairment of mobility requiring the use of a walking aid and/or dependence in functional activities of daily living requiring assistance 3. Short Physical Performance Battery (SPPB) score less than or equal to 10
Exclusion criteria
Exclusion criteria: 1. Already in receipt of ACE inhibitor or angiotensin-receptor blocker (ARB) 2. Contraindication to ACE inhibitor use (significant aortic outflow obstruction; estimated glomerular filtration rate [eGFR] less than 30 ml/hr; serum potassium greater than 5.0 mmol/l, systolic blood pressure [BP] less than 90 mmHg) 3. Clinical diagnosis of heart failure 4. Undiagnosed heart failure (left ventricular systolic dysfunction on echocardiography) 5. Regular participation in exercise training 6. Moderate to severe cognitive impairment (Mini-Mental State Examination [MMSE] less than 20/30) 7. Wheelchair bound 8. Unwilling to participate
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Measured at baseline, 10 and 20 weeks: 1. Short Physical Performance Battery (score range 0 worst function to 12 best function) 2. Hand grip strength and quadriceps strength measured using dynamometry 3. Functional Limitation Profile questionnaire 4. Health-related quality of life measured using the EuroQol questionnaire | — |
Primary
| Measure | Time frame |
|---|---|
| Six-minute walking distance, measured at baseline, 10 and 20 weeks | — |
Countries
United Kingdom
Outcome results
None listed