Circadian modulation of retinal function Eye Diseases
Conditions
Interventions
Ultra-short sleep-wake cycle intervention:
All participants undergo the same protocol and there are no study arms. The intervention is geared to decouple circadian from homeostatic parameters. Partici
Sponsors
Max Planck Institute for Biological Cybernetics
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Good physical health 2. Good mental health 3. Good ocular health 4. Normal or corrected-to-normal vision 5. Normal colour vision
Exclusion criteria
Exclusion criteria: 1. Too low (25) BMI 2. Alcohol abuse (AUDIT >7) 3. Self-report of depressive symptoms 4. Self-report of history of anxiety disorder 5. Extreme chronotype 6. Any use of medications (except for hormonal contraception) 7. Smoking 8. Photosensitive epilepsy 9. Shift work 10 . Transmeridian travel 11. Pregnancy 12. Endocrine alterations 13. Drug use during the study 14. Alcohol use during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Pupil responses to silent-substitution modulations (L-M, S, L+M+S, Mel) are measured once using a Maxwellian multi-primary pupillometer during each ultra-short sleep-wake cycle 2. Psychophysical thresholds to silent-substitution modulations (L-M, S, L+M+S) are measured once using the Metropsis stimulus system during each ultra-short sleep-wake cycle | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Core body temperature is measured using telemetry pills continuously during the entire experiment. 2. Distal-proximal temperature measured using skin temperature sensors continuously during the entire experiment. 3. Rest-activity cycles are measured using actigraphs continuously during the entire experiment. 4. ECG is measured using a heart rate monitor continuously during the entire experiment. 5. Glucose concentrations are measured using a CGM continuously during the entire experiment. 6. Ocular structures are measured using OCT once per ultra-short sleep-wake cycle 7. Salivary cortisol concentrations are measured using Salivette and later ELISAs every 45 minutes during each ultra-short sleep-wake cycle 8. Salivary melatonin concentrations are measured using Salivette and later ELISAs every 45 minutes during each ultra-short sleep-wake cycle 9. Intraocular pressure is measured using a tonometer once per ultra-short sleep-wake cycle 10. Psychomotor vigilance is measured using the Psychomotor Vigilance Test (PVT) once per ultra-short sleep-wake cycle 11. Blood pressure is measured using a wearable blood pressure monitor every 45 minutes per ultra-short sleep-wake cycle | — |
Countries
Germany
Contacts
Public ContactManuel;Hannah Spitschan;Heinrichs
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Outcome results
None listed