Outcome of nicotine replacement therapy in the patients admitted to Intensive Care Unit

Outcome of nicotine replacement therapy in the patients admitted to Intensive Care Unit: a randomised case-control double blinded prospective trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN66928309

Enrollment

Registered

2010-08-10

Start date

2009-01-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Smoking cessation Mental and Behavioural Disorders Smoking cessation

Interventions

Interventional arm: After randomising patients into case and control, we applied nicotine patch containing nicotine 21 mg on the skin for patients who were cases. We applied it every day until patient

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Smoker (greater than 1 pack per day [ppd] for greater than 1 year) 2. Admitted to ICU 3. Consent required either from patient or from surrogate 4. Aged greater than 18 years, either sex

Exclusion criteria

Exclusion criteria: 1. Pregnant 2. Myocardial infarction (MI) in last 2 weeks 3. Uncontrolled or serious arrhythmia 4. Severe allergic reaction to nicotine or patch 5. Peptic ulcer disease 6. Hyperthyroidism

Design outcomes

Primary

Measure	Time frame
1. Decreased ICU stay, measured after the patient is out of ICU 2. Increased ventilator free days, measured when patient is breathing without the help of ventilator	—

Secondary

Measure	Time frame
Decreased use of sedation and analgesia, measured at the end of ICU stay	—

Countries

United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 24, 2026