UK Trial of Radioiodine Intervention in Subclinical Hyperthyroidism

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN66874446

Enrollment

780

Registered

2006-08-08

Start date

2006-10-01

Completion date

Unknown

Last updated

2017-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hyperthyroidism Nutritional, Metabolic, Endocrine Subclinical hyperthyroidism

Interventions

Radioiodine treatment versus usual care.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Over 65 years of age 2. Sustained subclinical hyperthyroidism (undetectable Thyroid Stimulating Hormome [TSH], normal free thyroid hormones) for greater than three months

Exclusion criteria

Exclusion criteria: 1. Patient currently has or has ever had Atrial Fibrillation (AF) 2. Certain drug usage 3. Pituitary, severe renal or hepatic disease 4. Unstable coronary disease

Design outcomes

Primary

Measure	Time frame
Composite circulatory mortality	—

Secondary

Measure	Time frame
1. All cause mortality 2. Atrial fibrillation 3. Progression to overt hyperthyroidism 4. Hip and vertebral fractures 5. MMTS	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026