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Extracellular vesicles and biliary stenoses

Extracellular vesicles in human bile as a novel and accurate marker of malignant biliary stenoses

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN66835592
Enrollment
50
Registered
2017-02-02
Start date
2009-11-02
Completion date
Unknown
Last updated
2018-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Common bile duct stenosis Digestive System Common bile duct stenosis

Interventions

Participants undergo a biliary catheterization through endoscopic exploration of the biliary tract. This involves bile being removed from the common bile duct after it has been aspirated. Bile is aliq

Sponsors

Service of Gastroenterology and Hepatology
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for biliary catheterism due to obstructive jaundice or cholestasis of biliary origin (suspicion of cancer, suspicion of stones, chronic pancreatitis) 2. Age > 16 years old

Exclusion criteria

Exclusion criteria: 1. Less than 16 years old 2. Pregnant women

Design outcomes

Primary

MeasureTime frame
1. Extracellular vesicles (EVs) are evaluated by transmission electron microscope (TEM) and nanoparticle tracking analysis (NTA) and through medical interviews at baseline and 12 months 2. Serum bilirubin and CA19.9 are measured in all patients at baseline

Secondary

MeasureTime frame
Performance of extracellular vesicles (EVs) is assessed through tumor markers (including CA19-9) at baseline

Countries

Belgium, Switzerland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 10, 2026