Does nicorandil instead of supranormal potassium safely provide cardioplegia?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN66723294

Enrollment

Registered

2006-09-25

Start date

2005-01-24

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Angina pectoris Circulatory System Angina pectoris

Interventions

Two groups of cardioplegia randomised to receive either: 1. Standard St. Thomas Hospital Solution (high [16 mM] potassium cardioplegia) 2. Nicorandil

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 40 to 75 years 2. Elective to Coronary Artery Bypass Graft (CABG) 3. Ejection Fraction (EF) more than 40%

Exclusion criteria

Exclusion criteria: 1. Concomitant procedures 2. Emergency procedures 3. Glibenclamid medication 4. Pregnancy

Design outcomes

Primary

Measure	Time frame
1. Creatine Kinase Myocardial Band (CKMB) 2. Troponin 3. Cardiac Index (CI) 4. Saphenous Vein (SV) 5. Systemic Vascular Resistance (SVR) 6. Heart rate (HR) 7. Time to arrest	—

Secondary

Measure	Time frame
Quality of life	—

Countries

Norway

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026