Can High Flow Nasal Prongs therapy facilitate earlier establishment of full oral feeds in babies who are Nasal Continuous Positive Airway Pressure dependent at 32 weeks gestation?

High Flow Nasal Prongs (HFNP) therapy versus Nasal Continuous Positive Airway Pressure (NCPAP) in establishing full oral feeds in Very Low Birth Weight (VLBW) infants - randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN66716753

Enrollment

Registered

2013-03-14

Start date

2013-02-01

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Establishment of full oral bottle / breast feeding in preterm infants Pregnancy and Childbirth Other preterm infants

Interventions

Intervention Group: Use of High Flow Nasal Prongs therapy starting at 32 weeks of corrected gestational age Control Group: Use of Nasal Continuous Positive Airway Pressure at 32 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Very Low Birth Weight Infants (1500g or less) 2. Born at less than 30 weeks gestation (24+0 to 29+6) 3. Neonates requiring respiratory support in the form of NCPAP at 32 weeks corrected gestational age with an oxygen requirements of less than 30% 4. Infants requiring positive end expiratory pressure (PEEP)<5 cm H2O and breathing in room air will first be offered a trial off NCPAP with no respiratory support, but if this fails they will then be eligible for randomization 5. Full enteral feeding (by nasogastric or orogastric tube)

Exclusion criteria

Exclusion criteria: Significant congenital / respiratory / cardiac / airway abnormality at the time of randomization

Design outcomes

Primary

Measure	Time frame
The establishment of full oral feeding - days from 32 weeks corrected gestational age	—

Secondary

Measure	Time frame
Duration of respiratory support - days from 32 weeks corrected gestational age	—

Countries

Ireland

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 28, 2026