Typhoid fever Infections and Infestations Typhoid fever
Conditions
Interventions
A randomised, open clinical trial with random allocation to three days ofloxacin or three days azithromycin.
Please note that the anticipated end date has been extended to 31st December 2008.
Sponsors
University of Oxford (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult (more than or equal to 15 years, either sex) non-pregnant patients with suspected or blood culture proven typhoid 2. Fever more than 37.5 °C 3. Informed written consent to the study 4. Able to stay in hospital for seven days 5. Able to take oral medication 6. Body weight more than 40 kg 7. Likely to be able to complete six months follow up 8. None of the exclusion criteria
Exclusion criteria
Exclusion criteria: 1. Known hypersensitivity to ofloxacin or azithromycin 2. Administration of chloramphenicol, co-trimoxazole, ampicillin, azithromycin or a fluoroquinolone during the previous week 3. Pregnancy or breast feeding 4. Contraindications to ofloxacin or azithromycin 5. Evidence for severe typhoid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measures are fever clearance, cure rate, relapse rate and S. typhi stool carriage rate. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcome measures | — |
Countries
Laos
Outcome results
None listed