Surgical treatment outcomes in patients with different pulmonary diseases caused by Mycobacteria

Surgical treatment outcomes in patients with a diagnosis of nontuberculous mycobacterial pulmonary disease, a combination of nontuberculous mycobacterium pulmonary disease and pulmonary tuberculosis, or cavitary pulmonary tuberculosis: a retrospective observational study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN66445153

Enrollment

Registered

2021-11-17

Start date

2011-06-11

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical outcomes of patients with nontuberculous mycobacterial pulmonary disease, a combination of nontuberculous mycobacterium pulmonary disease and pulmonary tuberculosis, or cavitary pulmonary tuberculosis Surgery

Interventions

This study will investigate the outcomes of treatment in a cohort of patients admitted to hospital between January 2011 and December 2017, who underwent resectional lung surgery for nontuberculous myc

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Surgery performed at Sechenov University Phthisiopulmonology Clinical Hospital to treat one of the following: 1. Nontuberculous mycobacterial pulmonary disease between 2011 and 2021 2. A combination of nontuberculous mycobacterium pulmonary disease and pulmonary tuberculosis between 2011 and 2021 3. Cavitary pulmonary tuberculosis from 2016 to 2017

Exclusion criteria

Exclusion criteria: 1. Admitted before January 2011 and after December 2017 2. Received lung resections and/or do not have the nontuberculous mycobacterial pulmonary disease, a combination of nontuberculous mycobacterium lung disease and pulmonary tuberculosis, or cavitary pulmonary tuberculosis

Design outcomes

Primary

Measure	Time frame
1. Sputum culture conversion after surgery measured using microscopic examination (AFB smear); samples, which were cultured on Lowenstein–Jensen (L-J) medium and molecular diagnostic testing after surgery 2. 30 -day postoperative mortality rate measured using patient records at 30 days post-surgery 3. Intra- and postoperative complications measured using patient follow-up at 1, 3, and 5 years post-surgery 4. Postoperative mortality due to pulmonary disease and any other possible causes measured using patient follow-up at 1, 3, and 5 years post-surgery	—

Measure

Time frame

1. Sputum culture conversion after surgery measured using microscopic examination (AFB smear); samples, which were cultured on Lowenstein–Jensen (L-J) medium and molecular diagnostic testing after surgery 2. 30 -day postoperative mortality rate measured using patient records at 30 days post-surgery 3. Intra- and postoperative complications measured using patient follow-up at 1, 3, and 5 years post-surgery 4. Postoperative mortality due to pulmonary disease and any other possible causes measured using patient follow-up at 1, 3, and 5 years post-surgery

—

Secondary

Measure	Time frame
1. Sputum culture conversion rate measured using microscopic examination (AFB smear); samples, which were cultured on Lowenstein–Jensen (L-J) medium and molecular diagnostic testing after surgery and at 1, 3, and 5 years post-surgery 2. Presence of cavities in pulmonary tissue (CV+/CV-) measured using CT scan/digital X-ray on discharge from hospital at 1, 3, and 5 years post-surgery 3. Five-year survival rate measured using patient follow-up at 5 years post-surgery	—

Measure

Time frame

1. Sputum culture conversion rate measured using microscopic examination (AFB smear); samples, which were cultured on Lowenstein–Jensen (L-J) medium and molecular diagnostic testing after surgery and at 1, 3, and 5 years post-surgery 2. Presence of cavities in pulmonary tissue (CV+/CV-) measured using CT scan/digital X-ray on discharge from hospital at 1, 3, and 5 years post-surgery 3. Five-year survival rate measured using patient follow-up at 5 years post-surgery

—

Countries

Russian Federation

Contacts

Public ContactLyudmila Severova

severova_l_p@staff.sechenov.ru+79037394349

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026