Nordic Long-term Obsessive compulsive disorder (OCD) Treatment Study

Conditions

Obsessive compulsive disorder Mental and Behavioural Disorders Obsessive compulsive disorder

Nor Christian Torp, Davíð R.M.A. Højgaard, Marianne Aalberg, Katja Anna Hybel, Gudmundur Skarphéðinsson et al. (11 authors)

Nordic Journal of Psychiatry2025-07-09

10.1080/08039488.2025.2528075

Remission and Relapse Across Three Years in Pediatric Obsessive-Compulsive Disorder Following Evidence-Based Treatments.

Ivarsson T, Jensen S, Højgaard DRMA, Hybel KA, Torp NC, Melin K, Nissen JB, Weidle B, Thomsen PH, Dahl K, Skarphedinsson G.

2023-12-075 citations

10.1016/j.jaac.2023.09.548

Quality of life in pediatric patients with obsessive-compulsive disorder during and 3 years after stepped-care treatment.

Jensen S, Hybel KA, Højgaard DRMA, Nissen JB, Weidle B, Ivarsson T, Skarphedinsson G, Melin K, Torp NC, Carlsen AH, Mortensen EL, Lenhard F, Compton S, Thomsen PH.

2021-04-218 citations

10.1007/s00787-021-01775-w

Health anxiety symptoms in pediatric obsessive-compulsive disorder: patient characteristics and effect on treatment outcome.

Duholm CS, Højgaard DRMA, Skarphedinsson G, Thomsen PH, Rask CU.

2021-04-167 citations

10.1007/s00787-021-01774-x

Distinct trajectories of long‐term symptom severity in pediatric obsessive–compulsive disorder during and after stepped‐care treatment

Sanne Jensen, Davíð R.M.A. Højgaard, Katja Anna Hybel, Erik Lykke Mortensen, Gudmundur Skarphéðinsson et al. (14 authors)

Journal of Child Psychology and Psychiatry2019-11-1717 citations

10.1111/jcpp.13155

Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS.

Melin K, Skarphedinsson G, Thomsen PH, Weidle B, Torp NC, Valderhaug R, Højgaard DRMA, Hybel KA, Nissen JB, Jensen S, Dahl K, Skärsäter I, Haugland BS, Ivarsson T.

2019-02-1434 citations

10.1016/j.jaac.2019.01.010

One-Year Outcome for Responders of Cognitive-Behavioral Therapy for Pediatric Obsessive-Compulsive Disorder.

Højgaard DRMA, Hybel KA, Ivarsson T, Skarphedinsson G, Becker Nissen J, Weidle B, Melin K, Torp NC, Valderhaug R, Dahl K, Mortensen EL, Compton S, Jensen S, Lenhard F, Thomsen PH.

2017-09-1326 citations

10.1016/j.jaac.2017.09.002

Pediatric obsessive-compulsive disorder with tic symptoms: clinical presentation and treatment outcome.

Højgaard DRMA, Skarphedinsson G, Nissen JB, Hybel KA, Ivarsson T, Thomsen PH.

2016-12-2812 citations

10.1007/s00787-016-0936-0

Early responders and remitters to exposure-based CBT for pediatric OCD

Nor Christian Torp, Gudmundur Skarphéðinsson

Journal of Obsessive-Compulsive and Related Disorders2016-12-2228 citations

10.1016/j.jocrd.2016.12.007

Predictors Associated With Improved Cognitive-Behavioral Therapy Outcome in Pediatric Obsessive-Compulsive Disorder

Nor Christian Torp, Kitty Dahl, Gudmundur Skarphéðinsson, Scott N. Compton, Per Hove Thomsen et al. (11 authors)

Journal of the American Academy of Child & Adolescent Psychiatry2014-12-20112 citations

10.1016/j.jaac.2014.12.007

Effectiveness of cognitive behavior treatment for pediatric obsessive-compulsive disorder: Acute outcomes from the Nordic Long-term OCD Treatment Study (NordLOTS)

Nor Christian Torp, Kitty Dahl, Gudmundur Skarphéðinsson, Per Hove Thomsen, Robert Valderhaug et al. (13 authors)

Behaviour Research and Therapy2014-11-21168 citations

10.1016/j.brat.2014.11.005

Quality of life in children with OCD with and without comorbidity

Bernhard Weidle, Thomas Jozefiak, Tord Ivarsson, Per Hove Thomsen

Health and Quality of Life Outcomes2014-10-2856 citations

10.1186/s12955-014-0152-x

Interventions

Step 1: Cognitive behaviour therapy (CBT) Step 2: Sertraline plus CBT support (less intensive CBT) or intensive CBT Step 3: Sertraline plus CBT support plus aripiprazol Non-responders to CBT are rand

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients 7 - 17 years of age 2. Moderate-severe obsessive compulsive disorder according to Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition (DSM IV). Severity is defined by Children's Yale-Brown Obsessive Compulsive Scales (CY-BOCS) scores of 16 or above

Exclusion criteria

Exclusion criteria: 1. Co-morbidity has not higher treatment priority (e.g. psychosis, anorexia nervosa, severe depression with suicidality, an autistic disorder or Asperger's syndrome) 2. Pervasive developmental disorders (PDD) not otherwise specified (NOS) is allowed if Clinical Global Impression (CGI) score for the PDD is less than or equal to 3 and CGI for the PDD NOS is less than or equal to CGI for the OCD 3. Mental retardation (intelligence quotient [IQ] less than 70) 4. Patients have not been treated with selective serotonin reuptake inhibitor (SSRI) or CBT for their OCD during the last year 5. If the patient is of non-Nordic ethnicity both the patient and one parent must speak a Nordic language

Design outcomes

Primary

Measure	Time frame
1. CYBOCS 2. Clinical Global Impression Scale 3. Clinical Global Improvement Scale 4. Children's OCD Impact Scale Outcomes measured (approximately) at weeks 0, 7, 13, and months 6, 12, 24, 36.	—

Secondary

Measure	Time frame
1. Screen for Child Anxiety Related Disorders Revised (SCARED-R) 2. Mood and Feelings Questionnaire (MFQ) 3. Children's Global Assessment Scale (CGAS) 4. Child Behaviour Checklist (CBCL) 5. Family Accomodation Scale (FAS) 6. Need to add another treatment Outcomes measured (approximately) at weeks 0, 7, 13, and months 6, 12, 24, 36.	—

Countries

Denmark, Norway, Sweden

Outcome results

None listed