Mild to moderate asthma in acute exacerbation Respiratory Asthma
Conditions
Interventions
According to Chinese cut-off criteria of obesity, the subjects with asthma are divided into four groups which are the underweight group with BMI less than 18.5 kg/m2, the normal group with BMI between
Sponsors
West China Hospital at Sichuan University (China)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Mild to moderate asthma in acute exacerbation 2. Male and female patients between 15 and 75 years 3. Within 72 hours of onset of acute asthma 4. Ability to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Use of systemic steroids or immunosuppressive agents within one month before recruitment, or history of life-threatening asthma requiring treatment with intubation and mechanical ventilation 2. Maintenance therapy with symbicort, or rescue therapy with formoterol or anticholinergic agents 3. Current alcoholism or drug abuse 4. Lung diseases other asthma 5. Severe diseases of cardiovascular, hepatic, renal, central nervous system, haematopoietic system cancer 6. Significant medical illness (other than asthma) that is not stable 7. History of respiratory tract infection within the previous 6 weeks 8. Pregnancy or breast-feeding 9. The inability to understand and complete this study 10. Peptic ulcer or gastrointestinal haemorrhage 11. Intolerance to beta-2-agonists or steroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of patients with use of systemic steroids and steroid dose, and the number of patients with hospital admission, which are evaluated at days 4 and 8. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The number of puffs of beta agonists (salbutamol) recorded in asthma diary by the patient himself every day during 7-day study 2. Lung functions (PEF), which are assessed at hours 0, 2, 4, 6, 8, 10, 12 after recruitment, and in morning and evening every day during 7-day of treatment | — |
Countries
China
Outcome results
None listed