Effect of dietary nitrate supplementation on exercise performance in chronic obstructive pulmonary disease (COPD)

EDEN-EPIC: Effect of dietary nitrate supplementation on exercise performance in COPD - a randomised double-blind cross-over placebo controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN66099139

Enrollment

Registered

2013-04-22

Start date

2013-05-01

Completion date

Unknown

Last updated

2016-11-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease (COPD) Respiratory Chronic obstructive pulmonary disease (COPD)

Interventions

Current interventions as of 03/06/2015: 140 ml concentrated beetroot juice or matched nitrate-depleted placebo. Previous interventions: 70 ml concentrated beetroot juice or matched nitrate-depleted p

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adult patients with a clinical and spirometric diagnosis of COPD, GOLD stage II-IV.

Exclusion criteria

Exclusion criteria: Clinically unstable patients (within one month of exacerbation), significant comorbidity limiting exercise tolerance, significant renal impairment (estimated glomerular filtration rate (eGFR) <50 ml.min-1), hypotension (systolic blood pressure <100 mmHg), pregnancy, use of nitrate based medication, other reason for benefit from nitrate supplementation (ischaemic heart disease, peripheral arterial disease), use of long-term oxygen therapy.

Design outcomes

Primary

Measure	Time frame
Time to exhaustion in a fixed workload cycle ergometer test at 70% VO2max	—

Secondary

Measure	Time frame
1. Area under VO2 curve to isotime (VO2) during endurance cycle ergometry 2. Fractional oxygen extraction of quadriceps muscle as assessed by NIRS	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 3, 2026