Treatment of acne with red light photodynamic therapy

The efficacy and safety of "low-dose" 5-aminolevulinic acid (ALA) thermosetting gel photodynamic therapy in the treatment of mild to moderate acne vulgaris

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN66066651

Enrollment

Registered

2018-02-01

Start date

2017-05-01

Completion date

Unknown

Last updated

2020-12-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild to moderate acne vulgaris Skin and Connective Tissue Diseases Acne vulgaris

Interventions

ALA 5% gel single application was gently applied 2.5 g on the face and rubbed until complete absorption. After 120 minutes of “incubation” in a dark room, a PDT session (15 minutes under red light la

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Mild to moderate acne vulgaris

Exclusion criteria

Exclusion criteria: 1. Severe acne 2. Skin phototype I 3. Positive history of skin tumor 4. Photodermatosis

Design outcomes

Primary

Measure	Time frame
Acne severity, assessed using the Global Acne Grading System (GAGS) score according to Doshi (Int J Dermatol 1997 36:416) at baseline, after the third PDT session and at the follow-up visit. A GAG score of 1-18 is considered mild; 19-30, moderate; 31-38, severe; and >39, very severe.	—

Secondary

Measure	Time frame
Patient-reported local tolerability score (a 4-item grading scale: 0: no skin discomfort; 3: severe skin discomfort) after each PDT session	—

Countries

Italy

Contacts

Public ContactMassimo Milani

massimomilani1959@gmail.com+39 (0)29654231

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 24, 2026