Cardiac surgery will Cardiopulmonary Bypass Circulatory System
Conditions
Interventions
All eligible participants are invited to take part in the study after their cardiac surgery consultation and provided with a patient information leaflet. Participants interested in taking part in the
Sponsors
University of Leicester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Undergoing cardiac surgery involving cardiopulmonary bypass 2. Native English speaker (for neuropsychological tests) 3. Eligible to undergo MRI scan
Exclusion criteria
Exclusion criteria: Unable to take neuropsychological tests
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number and size of brain lesions assessed using 3T MRI imaging (including diffusion-weighted imaging, fluid-attenuated inversion recovery, time of flight angiography, susceptible weighted imaging and T1 and T2 volumetric measurements) before surgery and 6-8 weeks post-surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cognitive ability (including speed of information and language processing, attention and psychomotor speed) assessed using WASI test (via Block Design, Pattern Matrices, and Similarities and Vocabulary tests), Trail Making Parts A and B, WMS-III digit span task, SCOLP test and Grooved Pegboard test before surgery and 6-8 weeks post-surgery 2. Interruption to blood flow to the brain and presence of emboli during the surgical procedure assessed using intra-operative transcranial ultrasound monitoring of the middle cerebral artery 3. Presence/absence of risk factors for cognitive decline assessed by reviewing the participant's medical records | — |
Countries
United Kingdom
Contacts
Public ContactEmma Chung
Outcome results
None listed