Topic: Reproductive Health, Disease: Reproductive Health & Childbirth, Paediatrics Pregnancy and Childbirth
Conditions
Interventions
Particpants are randomized to two groups:
1. Early cord clamping: clamping of the cord within ten seconds after birth
2. Delayed cord clamping: clamping of the cord 45-60 seconds after birth
Sponsors
Clinic University Hospital Virgen de la Arrixaca (Spain)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Women will be eligible for the study if they are likely to have a live birth before 34 weeks gestation, regardless of mode of birth or whether cephalic or breech presentation, singleton or dichorionic pregnancies.
Exclusion criteria
Exclusion criteria: 1. Major fetal abnormalities (defined as those that are lethal or require prenatal or postnatal surgery) 2. Fetal growth restriction 3. Monochorionic twins 4. Maternal pathology (pregestational Diabetes, severe cardiopathy, etc) 5. Infectious disease, hypertension and/or preeclampsia, obstetrics complications (abruptio, etc)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of neonatal hemoglobin, hematocrit and bilirrubin levels within the first 7 days after birth | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Neonatal hemoglobin, hematocrit and ferritin at six months of life will be evaluated by blood sampling 2. Neonatal complications (Intraventricular hemorrhage, necrotizing enterocolitis, retinopathy, sepsis, respiratory problems, days on ventilation or oxygen, need for phototherapy, transfusions) and days in the neonatal intensive care will be evaluated by medical history review 3. Cardiac output in the first week after birth will be measured by echocardiography 4. Blood loss in the mother (blood test 48 hours after birth) 5. Neurodevelopmental assessment of newborns at the age of two-three years in both groups of the study will be test by Bayley Scales of Infant Development | — |
Countries
Spain
Outcome results
None listed