Neurosciences, psychiatry Mental and Behavioural Disorders Schizophrenia
Conditions
Interventions
Cognitive behaviour therapy/drug treatments
Sponsors
Medical Research Council (MRC) (UK)
Eligibility
Inclusion criteria
Inclusion criteria: Consecutive sample of in- or day-patients admitted with 1st and 2nd episode schizophrenia aged 18-65. Further inclusion criteria: 1. Able to give informed consent 2. Meet Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSMIV) diagnostic criteria for schizophrenia, schizophreniform or schizoaffective disorder with at least a 1 month history of positive symptoms 3. No significant history of organic brain disease or substance misuses for major aetiological factor for psychosis 4. Positive and negative syndrome scale (PANSS) for schizophrenia score of at least 4 on item hallucinatory behaviour and/or item delusions 5. Score of less than 5 on PANSS item conceptual disorganisation
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Change on core symptom scores on hallucination and delusion rating scales 2. Change in total symptoms scores on PANSS 3. Time to criterion of 50% recovery operationally defined - 4. Number of days in hospital before 1st discharge and during follow-up 5. Time to relapse 6. Follow-up symptom and outcome scores at 3.9 and 18 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
United Kingdom
Outcome results
None listed