Smoking cessation Mental and Behavioural Disorders Mental and behavioural disorders due to use of tobacco
Conditions
Interventions
Participants are randomised to the training group or the drug group
Drug group:
Participants would receive either varenicline or placebo in tablet form. Varenicline wo
Sponsors
University of Bristol (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Smokes > 10 manufactured cigarettes or > 15 roll up cigarettes per day 2. Smokes within one hour of waking 3. Aged between 18 and 40 years 4. Able to attend all of the study session 5. English as first language or equivalent level of fluency
Exclusion criteria
Exclusion criteria: 1. Female volunteers who are pregnant or breast feeding 2. Female volunteers not using adequate contraception 3. Volunteers who do not currently have a GP 4. Current or previous substance or alcohol misuse or dependence [other than nicotine] 5. Alcohol use in excess of 35 Units/week if female or 50 Units/week if male 6. Caffeine use = 8 cups per day 7. Significant current or past psychiatric illness (Axis 1 or 2 psychiatric diagnoses) as diagnosed by a psychiatrist 8. Clinically significant abnormality including cardiology risk factors and history of arrhythmia (as assessed by self-report) 9. Ongoing use of medication (i.e. intake of any medication within 8 weeks of study, with exception of local treatment and occasional paracetamol or non-steroidal anti-inflammatory drugs, e.g., aspirin or ibuprofen) 10. Smokers actively trying to give up smoking during the study period 11. Uncorrected visual impairment (including colour-blindness) 12. Uncorrected auditory impairment 13. Condition that makes MRI scanning unsafe (e.g. metallic implants; history of metal-working) 14. Unable to tolerate scanning environment (as established during a short anatomical MRI scan on day 0) 15. Hypersensitivity to Champix
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Neural responses to smoking-related cues 2. Cognitive bias | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Questionnaire of Smoking Urges 2. Minnesota Nicotine Withdrawal Scale (MNWS) | — |
Countries
United Kingdom
Outcome results
None listed