Low-dose radiation therapy in treating patients with follicular non-Hodgkin's lymphoma

A phase III multi-centre randomised controlled trial of low-dose palliative radiotherapy for follicular lymphoma

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN65687030

Enrollment

540

Registered

2005-12-01

Start date

2005-10-01

Completion date

Unknown

Last updated

2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-Hodgkin's follicular lymphoma Cancer Lymphoma

Interventions

Control arm: radiotherapy dosage of 24 Gy administered in 12 fractions Experimental arm: 4 Gy administered in two consecutive fractions

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The study population will consist of either male or females over the age of 18 years who are diagnosed with histologically proven follicular lymphoma, for whom palliative radiotherapy has been indicated by virture of tumour bulk or anatomical position.

Exclusion criteria

Exclusion criteria: 1. Stage 1A disease to be treated radically with radiotherapy 2. Histological sub-types other than follicular non-Hodgkin's lymphoma 3. Predicted prognosis less than 3 months 4. Chemotherapy within 4 weeks of planned radiotherapy

Design outcomes

Primary

Measure	Time frame
Local progression-free interval	—

Secondary

Measure	Time frame
1. Acute toxicity 2. Late toxicity 3. Tumour response 4. Overall survival 5. Health economic assessment	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026