Lymphoma (non-Hodgkin's) Cancer Lymphoma (non-Hodgkin's)
Conditions
Interventions
Arm 1: CHOP will be given at 3-week intervals. After three cycles patients will be evaluated for response. Patients with stable or progressive disease will go off study. A total of six cycles will be
Sponsors
European Organisation for Research and Treatment of Cancer (EORTC) (Belgium)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with Ann Arbour stages III or IV follicular NHL (at initial diagnosis) who have relapsed after a minimum of two adequate non-anthracycline containing systemic chemotherapy regimens. Patients pre-treated with other chemotherapy regimens are not eligible for this trial. 2. Patients should have achieved remission on at least one of the prior regimens (i.e. either on the first or second regimen) 3. Remission duration upon one of the prior regimens should have been at least 3 months 4. Previous treatment should have been at least 4 month of single agent therapy (e.g. chlorambucil) and/or at least four consecutive cycles of polychemotherapy (e.g. CVP) or purine analogues. Patients treated with chemotherapy not fulfilling these criteria are not eligible. 5. Follicular NHL according to the Revised European/American Lymphoma (REAL) classification, i.e. follicle centre lymphoma, follicular (provisional cytological grades I [small cell], II [mixed small cell and large cell], III [large cell]) 6. Must be CD20 positive lymphoma 7. At least one mass should be present measurable by two perpendicular diameters by either physical or radiological examination 8. Aged 18 years or above 9. World Health Organization (WHO) performance status 0, 1 or 2 10. Patient information and written informed consent according to the rules of the respective country
Exclusion criteria
Exclusion criteria: Does not match inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
Australia, Belgium, Canada, Denmark, Egypt, France, Hungary, Italy, Netherlands, New Zealand, Norway, Poland, Slovakia, Slovenia, South Africa, Sweden, Switzerland, United Kingdom
Outcome results
None listed