Recovery of finger extension post-stroke with survivors who are moderately to severely impaired Nervous System Diseases
Conditions
Interventions
Participants are randomized into a single-arm intervention study to receive the wearable device delivering non-invasive dual stimuli. The device delivers a two-step stimulation: a mechanical tap that
Sponsors
University College London
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: For healthy volunteers: 1. Fluent in English and able to understand the protocol and provide informed consent; 2. Aged between 18 to 75 years old; 3. Normal vision or corrected vision (using contact lenses or glasses if needed); For stroke participants: 1. Fluent in English and able to understand the protocol and provide informed consent; 2. Aged between 18 to 75 years old; 3. Normal vision or corrected vision (using contact lenses or glasses if needed); 4. >6 months post-stroke; 5. Discharged from NHS support; 6. Fugl Meyer Assessment - Upper Extremity (FMAUE) scores between 23- 52 divided into three groups: (a)poor, (b)limited and (c)notable functional capacity).
Exclusion criteria
Exclusion criteria: For healthy volunteers: 1. Are pregnant or possibly pregnant; 2. Have metal in the brain, skull or forearm; 3. Have any infectious diseases; 4. Have issues with dermatitis or sensitive skin; 5. Clinical history/ diagnosis of neurological, musculoskeletal, or mental disorders (including stroke); 6. Have a pacemaker; 7. Have any disorders relating to blood clotting or wound healing; 8. Have tinnitus or other hearing ailments; 9. Have a clinical history or diagnosis of epilepsy, cerebrovascular disease, dementia or increased intracranial pressure; 10. Have a history of repetitive or severe head trauma; 11. Have any primary or secondary tumours in the CNS. For stroke participants: 1. Are pregnant or possibly pregnant; 2. Have metal in the brain, skull or forearm; 3. Have any infectious diseases; 4. Have issues with dermatitis or sensitive skin; 5. Clinical history/ diagnosis of neurological, musculoskeletal, or mental disorders (other than stroke); 6. Have a pacemaker; 7. Have any disorders relating to blood clotting or wound healing; 8. Have any lesions to the brain stem as a result of the stroke(s); 9. Have tinnitus or other hearing ailments; 10. Have a clinical history or diagnosis of epilepsy, cerebrovascular disease, dementia or increased intracranial pressure; 11. Have a history of repetitive or severe head trauma; 12. Have any primary or secondary tumours in the CNS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Increased reticulospinal drive associated with startle reflex activation measured using custom StartReact code via EMG before and after the administration of the PowerBead treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Neurostimulation data measured using AP/PA TMS with and without startle, before and after the administration of the PowerBead treatment. 2. Degree of finger extension measured using motion capture data collected via lab camera, before and after the administration of the PowerBead treatment. 3. Variances in pinch and grip strength measured using a digital pinch dynamometer and grip dynamometer respectfully, before and after the administration of the PowerBead treatment. 4. Variances in muscle tone in the bicep, wrist and fingers measured using the Modified Ashworth Scale, before and after the administration of the PowerBead treatment. | — |
Countries
England, United Kingdom
Contacts
Public ContactLaura Salisbury
Outcome results
None listed