Effectiveness of 3D-guided piezocision-assisted orthodontic surgery (a minimally invasive surgical technique) in accelerating the correction of severely crowded teeth

Evaluation of the efficacy of 3D-guided piezosurgery (a minimally invasive surgical technique) in accelerating orthodontic alignment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN65498676

Enrollment

Registered

2021-04-07

Start date

2019-12-01

Completion date

Unknown

Last updated

2023-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior teeth severe orthodontic crowding Oral Health Anomalies of tooth position

Interventions

With the aid of a computer-generated list of random numbers, the recruited patients will be assigned to two parallel groups with a 1:1 allocation ratio. The first group receive conventional orthodonti

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult healthy patients, male and female, age range 15-27 years 2. Severe crowding =7 (Little's irregularity index) 3. Permanent occlusion 4. All mandibular teeth exist (except third molars) 5. Good oral and periodontal health: 5.1. Probing depth <4 mm 5.2. No radiographic evidence of bone loss 5.3. Gingival index =1 5.4. Plaque index =1

Exclusion criteria

Exclusion criteria: 1. Medical problems that affect tooth movement (use of corticosteroid, NSAIDs) 2. Patients have anti indication for oral surgery (medical, social, psychological) 3. Presence of primary teeth in the mandibular arch 4. Missing permanent mandibular teeth (except third molars) 5. Poor oral hygiene or current periodontal disease: 5.1. Probing depth =4 mm 5.2. Radiographic evidence of bone loss 5.3. Gingival index >1 5.4. Plaque index >1 6. Patient had previous orthodontic treatment

Design outcomes

Primary

Measure	Time frame
1. Duration of tooth alignment measured at the end of treatment by calculating the time required time (in days) to achieve complete alignment of lower anterior teeth from the first day of treatment and up to 120-150 days of observation 2. Change in tooth alignment measured using the Little Index of Irregularity at 30 days after the onset of treatment 3. Change in tooth alignment measured using the Little Index of Irregularity at 60 days after the onset of treatment 4. Change in tooth alignment measured using the Little Index of Irregularity at last assessment when a complete alignment is achieved; this is expected between 90 to 120 days after the onset of treatment	—

Measure

Time frame

1. Duration of tooth alignment measured at the end of treatment by calculating the time required time (in days) to achieve complete alignment of lower anterior teeth from the first day of treatment and up to 120-150 days of observation 2. Change in tooth alignment measured using the Little Index of Irregularity at 30 days after the onset of treatment 3. Change in tooth alignment measured using the Little Index of Irregularity at 60 days after the onset of treatment 4. Change in tooth alignment measured using the Little Index of Irregularity at last assessment when a complete alignment is achieved; this is expected between 90 to 120 days after the onset of treatment

—

Secondary

Measure	Time frame
1. Pain measured using the visual analogue score (VAS) at baseline, 12, 24 and 48 hours 2. Discomfort measured using the visual analogue score (VAS) at baseline, 12, 24 and 48 hours 3. Swelling measured using the visual analogue score (VAS) at baseline, 12, 24 and 48 hours	—

Countries

Syria

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 11, 2026