Pulmonary embolism (PE) Circulatory System Pulmonary embolism (PE)
Conditions
Interventions
Clinical model to identify PE likely or unlikely, Ddimer blood test, randomised to receive either V/Q or CT for diagnosis of possible PE, in majority of cases would have ultrasound to rule out deep ve
Sponsors
Queen Elizabeth II Health Science Centre (Nova Scotia) (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Consecutive adult patients (18 years and older) of either sex, presenting with symptoms or signs suspected by a physician of being caused by acute pulmonary embolism (acute onset of new or worsening shortness of breath, chest pain, hemoptysis, presyncope or syncope) will be potentially eligible for this study.
Exclusion criteria
Exclusion criteria: 1. Deep vein thrombosis or pulmonary embolism within the previous 3 months 2. No worsening of the severity of pulmonary symptoms within the previous 2 weeks 3. Use of therapeutic doses of parenteral anticoagulants for greater than 48 hours 4. Co-morbid condition making life expectancy less than 3 months 5. Contradiction to contrast media 6. A need for long-term use of anticoagulants 7. Pregnancy 8. Age less than 18 years 9. Refusal to give informed consent 10. Geographic inaccessibility to follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptomatic venous thromboembolism. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Asymptomatic venous thromboembolism 2. Death 3. Bleed (major and minor) | — |
Countries
Canada
Outcome results
None listed