Squamous-cell cancer of the oral cavity or oropharynx Cancer Malignant neoplasm of oropharynx
Conditions
Interventions
Patients will have to be appointed for radiotherapy shortly after the surgery, i.e. as soon as the pathological specimens are evaluated. Postoperative radiotherapy will begin as soon as posible, i.e a
the assigned treatments will differ, however, with respect to the overall radiation treatment time: it will be 5 weeks in p-CAIR and 7 weeks in p-RTCT. The total dose at sites considered to be at inte
Sponsors
Polish Ministry of Science and Higher Education (Poland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Squamous-cell cancer of the oral cavity or oropharynx 2. Age at least 18 years 3. A written informed consent for participation in a trial 4. Macroscopically complete major surgery 5. Good performance status (ZUBROD 0-1) 6. White-cell count of at least 3500 per cubic millimeter 7. Platelet count of at least 100,000 per cubic millimeter 8. Creatinine clearence of more than 50 ml per minute 9. Aminotransferase and bilirubin values below twice the normal upper limit
Exclusion criteria
Exclusion criteria: 1. Patients after reconstructive surgery with free-style flaps 2. Patients with stage pT1N0 disease 3. History of invasive cancer (except for nonmelanoma skin cancer) 4. Prior treatment 5. Distant metastases 6. For female participants, pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative incidence of locoregional recurrence | — |
Secondary
| Measure | Time frame |
|---|---|
| Local control, nodal control, metastases-free survival, disease-free survival, second cancer free survival, overall survival, acute mucosal reaction score (Dische system), acute radiation and hematological morbidity (RTOG scoring system), late radiation morbidity (RTOG/EORTC scoring system) | — |
Countries
Poland
Outcome results
None listed