Influence of age on response to new generation blood-thinning medicines

Investigation of the effect of age on anticoagulant response to novel oral anticoagulants (direct thrombin inhibitors and FXa inhibitors) ex-vivo

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN65439252

Enrollment

Registered

2016-05-20

Start date

2013-10-01

Completion date

Unknown

Last updated

2022-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anticoagulation response Circulatory System Anticoagulation response

Interventions

Current interventions as of 21/09/2020: The study will recruit 30 elderly inpatients not on warfarin and 30 young medically stable subjects not on warfarin. A sample o

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Current inclusion criteria as of 21/09/2020: Older subjects: 1. >65 years old 2. Medically stable 3. Without liver dysfunction 4. Able to give informed consent Younger subjects: 1. 65 years old 2. Medically stable 3. Without liver dysfunction 4. Able to give informed consent 5. Suspected of vitamin K deficiency as evaluated by the use of dietary questionnaire Younger subjects: 1. <65 years of age 2. Healthy 3. Having a normal healthy diet as evaluated by the dietary questionnaire

Exclusion criteria

Exclusion criteria: 1. Less than 18 years of age 2. Liver dysfunction 3. Receiving anticoagulation therapy

Design outcomes

Primary

Measure	Time frame
Clotting time	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026