Reducing the frequency and severity of auditory hallucinations: the AVATAR clinical trial

Reducing the frequency and severity of auditory hallucinations: a randomised clinical trial of a novel Audio-Visual Assisted Therapy Aid for Refractory auditory hallucinations (AVATAR) compared to supportive counselling

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN65314790

Enrollment

142

Registered

2013-03-27

Start date

2013-06-01

Completion date

Unknown

Last updated

2022-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe mental illness Mental and Behavioural Disorders Mental disorder, not otherwise specified

Interventions

1. AVATAR therapy: an average of 6 x ½ hour weekly sessions 2. CONTROL therapy: supportive counselling also for 6 x ½ hour weekly sessions Six sessions of a half an hou

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Male or female, aged 18+ who have experienced persistent auditory hallucinations despite medical treatment

Exclusion criteria

Exclusion criteria: 1. Age under 18 2. Primary diagnosis of organic brain disease or substance dependency 3. Auditory hallucinations in a language not spoken by therapists

Design outcomes

Primary

Measure	Time frame
Current primary outcome measures as of 21/09/2017: Total score on the auditory hallucinations component of the Psychotic Symptoms Rating Scale PSYRATS-AH (Haddock et al., 1999), measured at baseline, 12 weeks and 6 months Previous primary outcome measures: Total score on the auditory hallucinations component of the Psychotic Symptoms Rating Scale PSYRATS-AH (Haddock et al., 1999), measured at baseline, 8 weeks, 12 weeks and 6 months	—

Measure

Time frame

Current primary outcome measures as of 21/09/2017: Total score on the auditory hallucinations component of the Psychotic Symptoms Rating Scale PSYRATS-AH (Haddock et al., 1999), measured at baseline, 12 weeks and 6 months Previous primary outcome measures: Total score on the auditory hallucinations component of the Psychotic Symptoms Rating Scale PSYRATS-AH (Haddock et al., 1999), measured at baseline, 8 weeks, 12 weeks and 6 months

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Secondary

Measure	Time frame
Current secondary outcome measures as of 21/09/2017: Voices outcomes: 1. Beliefs about Voices Revised BAVQ-R (Chadwicket al., 2000) 2. Voices Acceptance and Actions Scale (Shawyer et al., 2007) 3. Voice power differential scale (Birchwood et al., 2000) Global: 1. Scales for the Assessment of Positive and Negative Symptoms (SAPS/SANS - Andreasen,1984) 2. Psychotic Symptoms Rating Scale- Delusions (Haddock et al., 1999) 3. Modified Illness Perceptions Questionnaire (Watson et al 2006, Marcus et al 2014) 4. Calgary Depression Scale (Addington et al., 1993) Quality of life: 1. Manchester Short Assessment of Quality of Life - MANSA (Priebe et al., 1999) 2. EQ5-D (EuroQol, 1999) Service use: Client service receipt inventory (Beecham and Knapp, 2001) Measured at baseline, 12 weeks and 6 months Previous secondary outcome measures: Voices outcomes: 1. Beliefs about Voices Revised BAVQ-R (Chadwicket al., 2000) 2. Voices Acceptance and Actions Scale (Shawyer et al., 2007) 3. Voice power differential scale (Birchwood et al., 2000) Global: 1. Scales for the Assessment of Positive and Negative Symptoms (SAPS/SANS - Andreasen,1984) 2. Psychotic Symptoms Rating Scale- Delusions (Haddock et al., 1999) 3. Beliefs about problems (Watson et al., 2006) 4. Calgary Depression Scale (Addington et al., 1993) Quality of life: 1. Manchester Short Assessment of Quality of Life - MANSA (Priebe et al., 1999) 2. EQ5-D (EuroQol, 1999) Service use: Client service receipt inventory (Beecham and Knapp, 2001)	—

Measure

Time frame

Current secondary outcome measures as of 21/09/2017: Voices outcomes: 1. Beliefs about Voices Revised BAVQ-R (Chadwicket al., 2000) 2. Voices Acceptance and Actions Scale (Shawyer et al., 2007) 3. Voice power differential scale (Birchwood et al., 2000) Global: 1. Scales for the Assessment of Positive and Negative Symptoms (SAPS/SANS - Andreasen,1984) 2. Psychotic Symptoms Rating Scale- Delusions (Haddock et al., 1999) 3. Modified Illness Perceptions Questionnaire (Watson et al 2006, Marcus et al 2014) 4. Calgary Depression Scale (Addington et al., 1993) Quality of life: 1. Manchester Short Assessment of Quality of Life - MANSA (Priebe et al., 1999) 2. EQ5-D (EuroQol, 1999) Service use: Client service receipt inventory (Beecham and Knapp, 2001) Measured at baseline, 12 weeks and 6 months Previous secondary outcome measures: Voices outcomes: 1. Beliefs about Voices Revised BAVQ-R (Chadwicket al., 2000) 2. Voices Acceptance and Actions Scale (Shawyer et al., 2007) 3. Voice power differential scale (Birchwood et al., 2000) Global: 1. Scales for the Assessment of Positive and Negative Symptoms (SAPS/SANS - Andreasen,1984) 2. Psychotic Symptoms Rating Scale- Delusions (Haddock et al., 1999) 3. Beliefs about problems (Watson et al., 2006) 4. Calgary Depression Scale (Addington et al., 1993) Quality of life: 1. Manchester Short Assessment of Quality of Life - MANSA (Priebe et al., 1999) 2. EQ5-D (EuroQol, 1999) Service use: Client service receipt inventory (Beecham and Knapp, 2001)

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Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 12, 2026