Serum Provitamin D kinetic upon oral intake

Serum Provitamin D kinetic upon oral intake: an open label dose escalation study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN65263333

Enrollment

Registered

2011-12-21

Start date

2008-12-10

Completion date

Unknown

Last updated

2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitamin D supplementation Not Applicable

Interventions

1. Vitamin D groups monthly increasing doses of vitamin D, in detail 2000 I.U. Daily followed by 4000 I.U. and 8000 I.U in the presence of 1 mg calcium daily 2. Controls: none

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Healthy individuals, patients with type I allergy 2. Age 18-60 years 3. No excessive tanning in last 4 weeks 4. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Simultaneous participation in an other study 2. Expected incompliance 3. Pregnancy, lactation 4. Disease of the cardiovascular system, kidneys, thyroid gland 5. Malignant diseases 6. Malabsorbtion 7. Chronic infections 8. Planned exzessive tanning during the investigation time

Design outcomes

Primary

Measure	Time frame
Achievement of serum 25-hydroxyvitamin D concentrations above 100 nM on screening visits and 4 monthly study visits	—

Secondary

Measure	Time frame
1. Serum concentrations of calcium, phosphorus, creatinine 2. Monitor activation and phenotype of peripheral lymphocytes Assesed on screening visits and 4 monthly study visits	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026