Selective Laser Trabeculoplasty and its effect on fluid flow out of the eyes

A randomised study of different levels of total energy delivered in Selective Laser Trabeculoplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN65144700

Enrollment

Registered

2008-04-25

Start date

2006-11-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ocular hypertension (OHT) and primary open-angle glaucoma (POAG) Eye Diseases Glaucoma

Interventions

Participants will be randomised to one of two different levels of total energy: 1. Treated with a lower total energy to the drainage angle 2. Treated with a higher energy level (of approximately doubl

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participants aged 21 - 85 years, male and female 2. Newly diagnosed ocular hypertension and primary open-angle glaucoma that require treatment

Exclusion criteria

Exclusion criteria: 1. Previous intraocular surgery 2. Advanced glaucoma 3. Very high presenting intra-ocular pressure (greater than 35 mmHg)

Design outcomes

Primary

Measure	Time frame
1. Intra-ocular pressure: measured with a Goldmann's applanation tonometer, using a topical anaesthetic, and fluorescein as the disclosing agent. The right eye will be measured first, followed by measurement of the left. This sequence will be repeated three times. The three measurements for each eye will be averaged and reported as intra-ocular pressure. 2. Outflow facility: measured from the rate of decay of intra-ocular pressure in the supine position during application of a recording Schiötz or pneumotonometer over a period of 4 minutes. The "R" values of the curve at every 30-second time point will be manually entered into the McLaren tonography computer program. The program fits a second-degree polynomial by least squares to the nine data points and determines the best-fit values for time 0 and time 4 minutes by extrapolation. These initial and final values of the tonometer scale reading will be used to look up the value for the facility of outflow using the 1955 scale approved by the Committee on Standardisation of Tonometers. Outcomes will be measured at baseline, one month and three months.	—

Measure

Time frame

1. Intra-ocular pressure: measured with a Goldmann's applanation tonometer, using a topical anaesthetic, and fluorescein as the disclosing agent. The right eye will be measured first, followed by measurement of the left. This sequence will be repeated three times. The three measurements for each eye will be averaged and reported as intra-ocular pressure. 2. Outflow facility: measured from the rate of decay of intra-ocular pressure in the supine position during application of a recording Schiötz or pneumotonometer over a period of 4 minutes. The "R" values of the curve at every 30-second time point will be manually entered into the McLaren tonography computer program. The program fits a second-degree polynomial by least squares to the nine data points and determines the best-fit values for time 0 and time 4 minutes by extrapolation. These initial and final values of the tonometer scale reading will be used to look up the value for the facility of outflow using the 1955 scale approved by the Committee on Standardisation of Tonometers. Outcomes will be measured at baseline, one month and three months.

—

Secondary

Measure	Time frame
Complications, measured at baseline, one month and three months.	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026