Chronic cough Respiratory Chronic cough
Conditions
Interventions
Two capsaicin cough challenge tests performed:
1. Increasing doses are inhaled up to maximum tolerated dose
2. Doses are inhaled in a random order
3. Number of coughs and urge-to-cough intensity recor
Sponsors
University Hospitals South Manchester NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers 1. Over 18 years old 2. Normal lung function 3. No current or past history of chronic cough or chronic respiratory illness 4. No current or past history of chronic pain, irritable bowel syndrome or chronic headaches 5. No current or past history of psychiatric illness Asthmatics 1. Over 18 years old 2. Physician diagnosis of asthma 3. Objective evidence of bronchial hyper-reactivity (either positive bronchial provocation test or significant (>12%) reversibility in FEV1 following inhaled bronchodilator) 4. Stable asthma [forced expiratory volume in one second (FEV1) > 75% predicted, no acute exacerbations requiring oral corticosteroids within last 4 weeks] 5. Can safely omit long-acting bronchodilators (if taking) Chronic Cough Patients 1. Over 18 years old 2. Chronic cough, defined as a cough lasting longer than 8 weeks despite investigation and/or treatment trials for cough variant asthma, post-nasal drip and gastro-oesophageal reflux disease 3. Normal chest x-ray 4. Normal lung function 5. Can safely omit long-acting bronchodilators (if taking)
Exclusion criteria
Exclusion criteria: All participants: 1. Recent upper respiratory tract infection ( 10 pack year smoking history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of maximum cough responses between patient groups | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Comparison of cough threshold between patient groups 2. Comparison of urge-to-cough threshold between patient groups 3. Comparison of maximum cough responses and cough threshold in men and women | — |
Countries
United Kingdom
Outcome results
None listed