Hyperemesis gravidarum Pregnancy and Childbirth Hyperemesis gravidarum with metabolic disturbance
Conditions
Interventions
Three litres of 5% dextrose-0.9% saline or three litres of 0.9% saline solution infused intravenously over 24 hours.
Sponsors
University of Malaya (Malyasia)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Clinical hyperemesis gravidarum with dehydration 2. Age = 18 years 3. Pregnancy less than 16 weeks of gestation 4. A positive urine pregnancy test if pregnancy not confirmed by ultrasound 5. Urine ketone at least 1+ on admission 6. First admission for hyperemesis gravidarum in current pregnancy 7. Venous plasma glucose = 6 mmol/l 8. Venous sodium = 125 mmol/l
Exclusion criteria
Exclusion criteria: 1. Molar pregnancy 2. Women with underlying medical problem eg established gestational hypertension, diabetes, heart disease, renal disease, thyroid disorder 3. Suspected gastrointestinal causes of nausea and vomiting e.g. gastritis, gastroenteritis, peptic ulcer 4. Established non viable pregnancy 5. Preexisting medical condition that can cause or exarcebate nausea and vomiting (eg culture proven symptomatic urinary tract infection, dengue fever)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Resolution of ketonuria at 24 hours (using urine dipstick) 2. Well being at 24 hours using a Visual Numerical Rating scale (VNRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Correction of hyponatraemia (= 136 mmol/l) 2. Correction of hypochloraemia (= 100 mmol/l) 3. Hyperglycaemia (any glucose level = 8 mmol/l) 4. Nausea score at enrollment, 8. 16 and 24 hours (using VNRS) 5. Duration of intravenous (i.v.) rehydration during hospitalisation 6. Doses of of i.v. anti-emetic 7. Admission to discharge interval | — |
Countries
Malaysia
Outcome results
None listed