Indoor air quality Not Applicable
Conditions
Interventions
The first part of the project (Phase 1) is a study involving a cross-sectional design across eight locations (200 homes and their inhabitants) without intervention. A subsequent smaller study (Phase 2
Sponsors
Norwegian Institute for Air Research
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Recruitment is at a household level. Households must have: 1. At least one child under 5 years of age at the time of recruitment 2. Reside in one of the designated areas specified by each local sampling partner
Exclusion criteria
Exclusion criteria: 1. Household does not have a child under 5 years of age 2. Child spends more than 10 nights per month away from home 3. Any resident smokes inside the home
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Indoor air quality measured using low-cost air quality sensors over a 28-day period at baseline conditions (time=0) and 1-month post-intervention 2. Indoor levels of semi-volatile organic compounds measured using passive PDMS sorbent over a 28-day period at baseline conditions (time=0) and 1-month post-intervention 3. Outdoor, home-adjacent levels of semi-volatile organic compounds measured using passive PDMS sorbent over a 28-day period at baseline conditions (time=0) and 1-month post-intervention 4. Levels of semi- and non-volatile organic compounds measured in settled house dust by chemical extraction and instrumental analysis (composite, Day 1 and Day 28 of baseline period, and 1-month post-intervention) 5. Biological profiling of settled house dust, by gel clot LAL test and Amplicon sequencing (composite, Day 1 and Day 28, and 1-month post-intervention) 6. Indoor profiles of volatile organic compounds measured using passive sorbent over a 7-day period at baseline conditions (time=0) and 1-month post-intervention 7. Outdoor, home-adjacent profiles of volatile organic compounds measured using passive sorbent over a 7-day period at baseline conditions (time=0) and 1-month post-intervention 8. Biomarkers of chemical exposure in human urine, measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS) at Day 28 and 1-month post-intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Toxicological profiling of settled house dust (composite, Day 1 and Day 28), measured by bioassays for oxidative stress, cytotoxicity, endocrine disruption and immunotoxicity 2. Toxicological profiling of indoor aerosols measured using active sampler collection over a 28-day period at baseline conditions (time=0), measured by lung barrier integrity, inflammatory and oxidative stress response 3. Levels of chemical additives in household products measured using direct sampling or wiping and fast screening ambient mass spectrometry on Day 28 4. Self-perceived indoor air quality measured by questionnaire on Day 28 | — |
Countries
Czech Republic, England, Estonia, Italy, Netherlands, Portugal, Slovenia, Sweden, United Kingdom
Contacts
Public ContactMaja;Pawel Nipen;Rostkowski
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Outcome results
None listed