Cystic fibrosis Nutritional, Metabolic, Endocrine Cystic fibrosis
Conditions
Interventions
The study is divided into three parts. In the first, data collected during patients’ mandated cystic fibrosis Annual Review screen will be analysed. For this part, there is no direct patient involve
Sponsors
Liverpool Heart and Chest Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age = 17 years old 2. Attending the adult CF Unit at LHCH 3. Confirmed CF diagnosis (positive sweat test in childhood and by genotyping) 4. Able to provide informed consent
Exclusion criteria
Exclusion criteria: 1. Potentially pregnant or lactating 2. Refusal or inability to provide informed consent 3. Unable or unwilling to sit or stand to perform DCR in the radiology department 4. Unable or unwilling to follow tidal breathing instructions (e.g., holding breath or taking a deep breath) 5. Unable to perform reproducible spirometry and/or full pulmonary function studies within ATS-ERS criteria 6. Any serious or active medical or psychiatric illness, which in the opinion of the investigators, would interfere with subject treatment, assessment, or compliance with the protocol 7. For those in the validation part of the study: suffering an acute exacerbation of underlying CF 8. For those in the validation part of the study: known to be MRSA positive 9. For those in the validation or exacerbation parts of the study: significant radiation exposure within the last year (for example, numerous CT scans of chest) 10. Involved, either currently or recently, in other studies involving non-routine exposure to sources of ionising radiation
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. Microbial colonisation measured using patient records 2. The presence of CF-related diabetes (CFRD) measured using patient records 3. Height, weight and BMI measured using patient records | — |
Primary
| Measure | Time frame |
|---|---|
| 1. Lung function (in the form of diaphragmatic movement) and lung volume measured by dynamic chest radiography 2. Lung function (provided by spirometry or pulmonary function studies) 3. Lung volume (provided by body plethysmography). This information will be gathered at the time of data collection (i.e. retrospective analysis of Annual Screen dynamic chest radiographs, which already form part of standard care at our Trust) or during collection of dynamic chest radiographs. There is no follow-up of patients required, so as soon as dynamic radiographs are taken for the patients, data analysis can be performed. | — |
Countries
England, United Kingdom
Outcome results
None listed