Pain and somatosensory function in survivors of paediatric haematological malignancies Other
Conditions
Interventions
This single-centre cross-sectional observational cohort study will be carried out with adolescents and young people (aged 14-18 years) recruited from the Paediatric Haematology/Bone Marrow Transplant
iii) quantitative sensory testing
and iv) cognitive testing. This will be scheduled at a time chosen by the family and will take up to 2 hours with a refreshment break. Reimbursement for travle costs is available.
Sponsors
Great Ormond Street Hospital for Children NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Young people aged 14-18 years with a prior diagnosis and treatment of paediatric haematology malignancies attending the Great Ormond Street Hospital Haematology/BMT Late Effects clinic
Exclusion criteria
Exclusion criteria: Young people with significantly impaired comprehension (less than school level for 10 year old) or inadequate English language skills for sensory testing instructions. Patients with chronic Graft vs. Host Disease (GVHD) will be excluded as multiple comorbidities would increase heterogeneity of the sample.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alterations in somatosensory function measured at a single time point: 1. Neuropathy is measured using Pediatric-modified Total Neuropathy Scale 2. Thermal detection thresholds are measured using Senselab MSA Thermal Stimulator 3. Mechanical detection threshold is measured using von Frey monofilaments 4. Vibration detection threshold is measured using Rydel-Seiffer graded tuning fork 5. Mechanical pinprick threshold is measured using weighted pinprick stimulators 6. Pressure pain threshold is measured using Somedic SENSEBox algometer 7. Wind-up ratio is measured using weighted pinprick stimulator 8. Dynamic brush allodynia is measured using calibrated brush 9. Thermal hyperalgesia is measured using Somedic RollTemp 10. Mechanical sensitivity is measured using von Frey hairs 11. Brush allodynia is measured using calibrated brush 12. Pain sensitivity and/or tolerance is measured using Cold Pressor Test | — |
Secondary
| Measure | Time frame |
|---|---|
| Prevalence and type of chronic pain: 1. Pain history is measured using Case Report Form 2. Intensity of current pain is measured using Visual Analog Scales 3. Average pain over the last week is measured using Visual Analog Scales 4. Worst pain over the last week is measured using Visual Analog Scales Self-reported outcome measures: 5. Presence and frequency of different sensory and affective pain descriptors are measured using McGill questionnaire 6. Quality of life is measured using Paediatric Quality of Life Inventory 7. Anxiety is measured using State and Trait Anxiety Inventory 8. Pain catastrophizing is measured using Pain Catastrophizing Scale 9. Resilience is measured using Connor-Davidson Resilience Scale 10. Neuropathic pain is measured using Self-Report Leeds Assessment of Neuropathic Symptoms and Signs | — |
Countries
England, United Kingdom
Contacts
Public ContactNatasa Ganea
Outcome results
None listed