The clinical outcomes of using high frequency ventilation compared with conventional ventilation in children with severe respiratory failure

The clinical efficacy of high frequency ventilation compared with conventional ventilation with lung volume recruitment in severe pediatric acute respiratory distress syndrome: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN64665281

Enrollment

Registered

2015-10-19

Start date

2012-03-03

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome Respiratory

Interventions

We performed a randomized controlled trial enrolling pediatric patients (aged 1 month to 15 years from March 2012 to September 2014) who were diagnosed to have severe ARDS upon PICU admission. Informe

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged >1 month and <15 years with a diagnosis of ARDS from the PICU at King Chulalongkorn Memorial University Hospital

Exclusion criteria

Exclusion criteria: 1. Evidence/suspicion of congestive heart failure 2. Evidence of left atrial hypertension 3. Severe irreversible neurological injury or Intractable shock 4. The underlying disease was deemed irreversible or ARDS > 48 hours 5. Pre-existing air leak syndrome (e.g., pneumothorax or pneumomediastinum) or pre-existing cystic lung disease

Design outcomes

Primary

Measure	Time frame
Oxygenation response, PaO2/FiO2, Oxygen index, A-a gradient compare Pre-post lung volume recruitment. Timepoints: baseline, 1 hour, 2 hours, 3 hours, 6 hours and 24 hours after lung volume recruitment.	—

Secondary

Measure	Time frame
1. Duration of PICU stay 2. Morbidity/mortality in PICU	—

Countries

Thailand

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026