Fasiculation frequency in Amyotrophic Lateral Sclerosis (ALS) patients with definite or probable motor neuron disease Nervous System Diseases
Conditions
Interventions
Particiapnts who take part in the study will undergo a clinical assessment to capture details such as age, gender, presence/absence of fasiculation or other motor neurone signs, age and site of sympto
Sponsors
Newcastle upon Tyne Hospitals NHS Foundation Trust
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Adult male or female, willing and able to give informed consent 2. Aged 18 years old or over 3. ALS patients with definite or probable motor neuron disease based on the Awaji criteria, or currently under investigation for possible ALS
Exclusion criteria
Exclusion criteria: 1. Contra-indication to MRI scanning 2. Implanted cardiac defibrillator 3. Inability to lie flat in the MRI scanner 4. ALS patients in an advanced disease stage (ALSFRS-R < 25) with respiratory insufficiency (forced vital capacity (FVC) < 60%), on non-invasive ventilation or receiving percutaneous gastrostomy feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of fasciculation events detected by MUMRI in each body region measured using Count of fasciculation events detected in a 3-minute recording, by each of the scanner makes and magnet strengths, using MUMRI within each of the four predefined body regions, reported as number of fasiculation events per region at Visit 1 (Single Study Visit);Number of fasciculating muscles detected by MUMRI in each body region measured using Count of individual muscles demonstrating at least one fasciculation event , detected by each of the scanner makes and magnet strengths, using MUMRI within each of the four predefined body regions. Reported as total number of fasciculating muscles per region at Visit 1 (Single Study Visit) | — |
Countries
England, Scotland, United Kingdom
Contacts
Public ContactRoger Whittaker
Outcome results
None listed