Elective liver resection surgery Surgery Liver resection
Conditions
Interventions
The interventions will take place only during liver resection:
1. Conventional intra-operative haemodynamic management
2. Intra-opertive LiDCOrapid-guided haemodynamic management
3. Intra-operative oe
Sponsors
Charité - University Medicine Berlin (Charité - Universitätsmedizin Berlin) (Germany)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 18 years and over, either sex, undergoing elective liver resection in Charité - University Medicine Berlin, Campus Virchow-Clinic
Exclusion criteria
Exclusion criteria: 1. Aged less than 18 years 2. No written informed consent from patient 3. For female patients: pregnancy or lactation 3. Inability to communicate freely in the German language 4. Lack of willingness to safe and hand out pseudonymised data within the clinical study 5. Simultaneous participation of the patient in another study 6. Accommodation in an institution due to an official or judicial order 7. Members of staff of the Charité 8. Unclear history of alcohol used disorder 9. Advanced disease of the oesophagus of nasopharyngeal cavity 10. Operations in the area of the oesophagus or nasopharynx within the last two months 11. History of bleeding tendency e.g. Von Willebrands disease 12. Neurological or psychiatric disease 13. Chronic heart failure New York Heart Association (NYHA) class IV 14. American Society of Anaesthesiologists (ASA) classification greater than IV 15. Chronic renal failure with dependency of haemodialysis 16. Existence of a pulmonary oedema in the pre-operative chest x-ray 17. History of intracranial haemorrhage within one year 18. Allergy to gelatin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke volume before intra-operative start of liver resection | — |
Secondary
| Measure | Time frame |
|---|---|
| All determined within the study period of 8 post-operative days: 1. Intra-operative and post-operative haemodynamic parameters 2. Intra-operative and post-operative blood loss 3. (Cumulative) frequency of organ dysfunctions (cerebral, pulmonal, renal, abdominal, cardiovascular) 4. Post-operative liver function (LiMAx-test, ICG-Clearance, liver Doppler, laboratory tests: enzymatic and chemical parameters) 5. Peri-operative weight change 6. Post-operative incidence of infections 7. Satisfaction of the patients, the surgeons and anaesthetists 8. Time to fulfilling discharge criteria 9. Length of intensive care stay and hospital stay (LOS) 10. Quality of life measure (EQ-5D) 11. Laboratory tests: peri-operative endothelial and immunological alterations | — |
Countries
Germany
Outcome results
None listed