Prevention and treatment of dental caries in caries-inactive and active adults Oral Health
Conditions
Interventions
Patients with dental caries display distinctive physiochemical alterations of saliva and research into the relationship between salivary composition and caries activity has been inconclusive. This unb
Sponsors
Agencia Nacional de Investigación y Desarrollo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Systemically health adults between 18 and 35 years of age who are able to give their informed consent autonomously, with normal unstimulated and stimulated salivary flow rate, good general and oral health, ability to comply with the experimental protocol, no antibiotic use during the three months before the study and not using a fixed or removable orthodontic or devices.
Exclusion criteria
Exclusion criteria: Subjects with systemic diseases related with caries that affect the salivary flow (such as Sjögren's syndrome), who has periodontal diseases (except gingivitis), who that had taken antibiotics during the last three months, that regularly consumed alcohol or that takes medications daily known to alter salivary flow and smokers will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification of potential protective factors in unstimulated and stimulated saliva from caries-inactive and active subjects using mass spectrometry-based proteomics at baseline, one and three months | — |
Secondary
| Measure | Time frame |
|---|---|
| Characterization of unstimulated and stimulated saliva from caries-inactive and active subjects at baseline, one and three months based on: 1. Inorganic and biochemical composition measured using commercial laboratory kits 2. Protein and microbial composition measured using mass spectrometry-based proteomics | — |
Countries
Chile
Contacts
Public ContactJuliana Botelho
Outcome results
None listed