Postoperative pain in radical prostatectomy Surgery Postoperative pain
Conditions
Interventions
Amantadine versus Placebo comparison.
Trial details received: 12 September 2005
Sponsors
University Health Network, Toronto (Canada)
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Able to read and write English 2. Age 18 - 54 years or greater than 55 years, male 3. American Society of Anesthesiologists (ASA) class 1 to 3 4. Scheduled for elective radical prostatectomy 5. Body weight between 60 and 90 kg, Body Mass Index (BMI) less than or equal to 30
Exclusion criteria
Exclusion criteria: 1. Significant Central Nervous System (CNS), respiratory, cardiac, hepatic, renal or endocrine dysfunction and/or any significant sequelae 2. Contraindications allergies to, and/or past adverse reactions to opioid analgesics or amantadine 3. History of Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) axis I disorder or cognitive dysfunction 4. History of epilepsy or other seizures 5. History of chronic pain of at least 6 months duration 6. History of long-term opioid use for chronic pain 7. History of long-term use of amantadine or other antiparkinsonian drug 8. Ingestion of antiussive medication within 48 hours before surgery 9. History of alcohol or drug dependency/abuse of at least 6 months duration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hyperalgesia and opioid consumption. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess age differences in the intensity and course of secondary hyperalgesia after surgery. | — |
Countries
Canada
Outcome results
None listed