Protein metabolism in chronic kidney disease

Effects of a low protein diet and of a keto/amino acid supplemented very low protein diet on muscle protein metabolism and myostatin in patients with chronic kidney disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN64383094

Enrollment

Registered

2013-02-21

Start date

2013-01-10

Completion date

Unknown

Last updated

2017-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease Urological and Genital Diseases Chronic kidney disease, unspecified

Interventions

Low protein diet or supplemented very low protein dieT (vLPD) The research protocol is composed of two different studies: Study A: to determine how skeletal muscle protein metabolism adapt to a low

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged 18-79, both males and females 2. Non-diabetic CKD (Stages 4-5, estimated glomerular filtration rate [eGFR] 12-25 ml/min) 3. Compliance to treatment

Exclusion criteria

Exclusion criteria: 1. Evidence of congestive heart failure 2. Incapable of following study requirements to control diet 3. A recent myocardial infarction 4. Pregnancy 5. Unstable renal function 6. Recent (<3 months) infection history 7. Clinical evidence of gastrointestinal or liver diseases 8. Alcoholism 9. Drug abuse 10. Final diagnosis of malignancy

Design outcomes

Primary

Measure	Time frame
Protein metabolism measured at baseline and at the end of each six-week experimental period	—

Secondary

Measure	Time frame
Serum/muscle myostatin measured at baseline and at the end of each six-week experimental period	—

Countries

Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026