Ultra-early blood pressure variability in patients with acute ischemic stroke treated with intravenous thrombolysis Circulatory System
Conditions
Interventions
Participants will be randomly allocated (1:1) to either the treatment or the control group. One group will receive transcutaneous electrical acupoint stimulation for approximately 1 hour, from the beg
Sponsors
Beijing Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. No gender limit 2. Age =18 years old 3. Meet the diagnostic criteria of acute ischemic stroke 4. Consistent with the indications of intravenous thrombolysis
Exclusion criteria
Exclusion criteria: 1. Coagulopathy, severe liver and kidney dysfunction 2. Implantation of metal or electronic implantable devices such as a cardiac pacemaker 3. History of epilepsy 4. Being pregnant or breastfeeding, or intending to become pregnant within the next 6 months 5. Damage, inflammation, scar, etc. on the skin of the acupoints; Sensory disturbance or allergy to electrical stimulation) 6. Patients could not tolerate transcutaneous electrical stimulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Blood pressure values measured using a mercury sphygmomanometer at baseline, 15, 30, 45, and 60 min after the start of thrombolysis, and 10 min after the completion of thrombolysis 2. Calculated blood pressure variability values measured using data collected during the above 7 blood pressure values monitoring at baseline, 15, 30, 45, and 60 min after the start of thrombolysis, and 10 min after the completion of thrombolysis | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The level of alertness and agitated behavior in patients measured using the Richmond Agitation-Sedation Scale (RASS) at baseline, 30 and 60 min 2. The severity of a stroke measured using the National Institutes of Health Stroke Scale (NIHSS) at baseline, 30 and 60 min 3. The occurrence of adverse events (during thrombolysis: fluctuation of symptoms, aggravation of disease, forced cessation of thrombolysis, various bleeding, application of antihypertensive drugs, application of sedative drugs; after thrombolysis: ischemia aggravation, cerebral hemorrhage, rescue use of antihypertensive drugs, etc.) measured using data observed and recorded during the process of intravenous thrombolysis at any time | — |
Countries
China
Contacts
Public ContactJiaxuan Chen
Outcome results
None listed