Tic disorders Mental and Behavioural Disorders Tic disorders
Conditions
Interventions
In the aripiprazole group, a child psychiatrist initially prescribed 5.0 mg/d of aripiprazole, and then increased the dose in 5.0 mg/d increments as tolerated at visits every two weeks. The dose was r
Sponsors
Asan Medical Centre (South Korea)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 6 - 18 years 2. Gender: male or female 3. Diagnosis: tic disorders according to the Korean version of the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (KSADS-PL) 4. Severity: total tic scores greater than or equal to 22 on the Korean version of the Yale Global Tic Severity Scale
Exclusion criteria
Exclusion criteria: 1. Current mood disorders 2. Psychotic symptoms 3. Anxiety disorders except obsessive-compulsive disorder, which is the most common comorbid anxiety disorder in tic patients 4. Subjects with an intelligence quotient (IQ) of 70 or less by using the Korean version of the Wechsler Intelligence Scale for Children-Revised 5. Previous or current seizure episodes, electroencephalogram (EEG) abnormalities 6. Subjects had used aripiprazole previously 7. Any significant medical problems 8. Pregnancy
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. The Clinical Global Impressions-Improvement Scale (CGI-I) 2. The CGI-Severity of Illness Scale (CGI-S) 3. The Extrapyramidal Symptom Rating Scale (ESRS) Both primary and secondary outcomes were measured at every visit (baseline, two weeks, four weeks, six weeks, eight weeks). | — |
Primary
| Measure | Time frame |
|---|---|
| Yale Global Tic Severity Scale (YGTSS): the YGTSS is a semi-structured clinical interview designed to assess current tic severity, which yields three summary scores. Both primary and secondary outcomes were measured at every visit (baseline, two weeks, four weeks, six weeks, eight weeks). | — |
Countries
Korea, South
Outcome results
None listed