Worms and human immunodeficiency virus (HIV) Interaction Study - Epidemiology component

Intestinal helminth infections and schistosomiasis and their relation to human immunodeficiency virus-1 (HIV-1) incidence, disease progression and immunology in Mbeya Region, Tanzania - epidemiology component

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN63722214

Enrollment

18500

Registered

2009-08-19

Start date

2009-08-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Human immunodeficiency virus-1 (HIV-1) infection/helminth infections Infections and Infestations Human immunodeficiency virus [HIV] disease resulting in infectious and parasitic diseases

Interventions

This is an observational longitudinal study, implemented within the framework of a large, household based single-centre population-based cohort study (EMINI), which is conducted by the Mbeya Medical R

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Participation in the EMINI cohort study. Participants of all age groups and both sexes will be included.

Exclusion criteria

Exclusion criteria: The study will only include consenting members of households who participate in the EMINI study, no other exclusion criteria apply.

Design outcomes

Primary

Measure	Time frame
1. Hypothesis 1: Seroconversion to HIV since last study visit; applied tests: 1.1. Initial HIV screening with SD Bioline HIV1/2 1.2. Positive results retested with Enzygnost HIV1/2 Plus 1.3. Discordant results confirmed by Western Blot 2. Hypothesis 2: 2.1. Change in Karnofsky score 2.2. HIV staging 2.3. Presence/absence of opportunistic infections (all determined by medical examination) 2.4. Changes in viral load Assessed one and two years after deworming.	—

Measure

Time frame

1. Hypothesis 1: Seroconversion to HIV since last study visit; applied tests: 1.1. Initial HIV screening with SD Bioline HIV1/2 1.2. Positive results retested with Enzygnost HIV1/2 Plus 1.3. Discordant results confirmed by Western Blot 2. Hypothesis 2: 2.1. Change in Karnofsky score 2.2. HIV staging 2.3. Presence/absence of opportunistic infections (all determined by medical examination) 2.4. Changes in viral load Assessed one and two years after deworming.

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Secondary

Measure	Time frame
1. Prevalence of intestinal nematode infections and schistosomiasis in the study population, measured before worm treatment 2. Effect of albendazole and praziquantel treatment on helminth infection, measured one and two years after deworming 3. Helminth reinfection after deworming, measured one and two years after deworming Intestinal nematode and S. mansoni infection for all above outcomes will be diagnosed by Kato-Katz microscopy, S. haematobium infection by urine filtration and microscopy.	—

Measure

Time frame

1. Prevalence of intestinal nematode infections and schistosomiasis in the study population, measured before worm treatment 2. Effect of albendazole and praziquantel treatment on helminth infection, measured one and two years after deworming 3. Helminth reinfection after deworming, measured one and two years after deworming Intestinal nematode and S. mansoni infection for all above outcomes will be diagnosed by Kato-Katz microscopy, S. haematobium infection by urine filtration and microscopy.

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Countries

Tanzania

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026